Blasts, bone marrow mast cells, neutrophils, macrophages, and cardiac myocytes (140). Various triggers induce synthesis of ET-1 including TGF- and other growth factors, cold exposure, low shear stress, hypoxia, and angiotensin II (140); but its synthesis is reduced by nitric oxide (NO), natriuretic peptides, increased blood flow, and prostacyclinCD87 (UPAR)(141). ET-1 is also degraded by MMP-1, wh