Dipose tissue reserves. In this sample, girls who were growing faster and girls who were depositing lean mass had, on average, lower non-acute CRP. We interpret this as evidence that, in this energy-limited environment, these girls were subsidizing the increased costs of growth in early adolescence through decreasing investment in non-acute immune function. We also find that, regardless of puberta
Dipose tissue reserves. In this sample, girls who were growing faster and girls who were depositing lean mass had, on average, lower non-acute CRP. We interpret this as evidence that, in this energy-limited environment, these girls were subsidizing the increased costs of growth in early adolescence through decreasing investment in non-acute immune function. We also find that, regardless of puberta
Stigated models that included interaction terms between fat gain and age, as well as fat gain and a dichotomous growth velocity indicator (above or below 1 cm/year). We did not find any significant interactions between fat gain and these covariates of pubertal transition.| Shattuck-Heidorn et al.Evolution, Medicine, and Public HealthCONCLUSION AND IMPLICATIONSAs a lean population going through the
Ment in other energetic demands, such as reproduction or physical activity, also evidence trade-offs with nonacute immune function? Intriguingly, two recent studies support a hypothesis that there are some trade-offs between female reproductive function and higher levels of CRP. Though they do not| Shattuck-Heidorn et al.Evolution, Medicine, and Public Healthspecifically investigate non-acute CRP,
Egulates energy metabolism and storage and is also the site of immune and antibacterial responses [41, 42]. And it is well-known that a minimum level of body fat and the hormone leptin is necessary to maintain T-mediated immunity [43], and that leptin can regulate inflammatory immune processes, including stimulating Il-6 production in macrophages [44, 45]. This is congruent with our initial eviden
F for acute CRP attempts to avoid biasing our data with individuals who are actively experiencing immune responses. However, it is possible that we are including some girls who have slightly elevated CRP and low growth because they have recently been sick. More broadly, it is unclear whether these relatively slight differences in CRP would be measurable in populations with higher rates of inflamma
Ment in other energetic demands, such as reproduction or physical activity, also evidence trade-offs with nonacute immune function? Intriguingly, two recent studies support a hypothesis that there are some trade-offs between female reproductive function and higher levels of CRP. Though they do not| Shattuck-Heidorn et al.Evolution, Medicine, and Public Healthspecifically investigate non-acute CRP,
As an anti-inflammatory effect [51]. How other types of physical activity, such as that associated with agricultural lifestyles, relates to immune function is an important locus for future research. The dominant public health discourse concerning CRP is one of pathology and "chronic inflammation", yet for at least a decade human biologists working in non-Western populations have found lower CRP th