Nd their TTA codons have adaptive value to streptomycetes and not to other actinobacteria. As shown in Table 2, about half of these genes encode proteins likely to be closely implicated in gene regulation or signal transduction, although their targets are mostly unknown. They include five conserved paralogues of genes found in the whiJ cluster (see below for further discussion) and gene sets for h
Ehalf of the Federation of European Microbiological SocietiesG. Chandra K.F. ChaterTable 2. Streptomyces genes or gene clusters that frequently contain TTA codons* SCO number of gene *asterisk means TTA codons are absent from the S. coelicolor gene 0381*;0382*;0383 0683*;0684*;0685* Fraction of TTA-containing orthologues among 14 Streptomyces genomes (see note) 6/12; 5/9; 2/10 2/12; 4/13; 2/Func
Al best hit to rsbN is found next to nearly all bldN orthologues in actinomycete genomes; but, strikingly, the RsbN-like proteins are much more divergent than their BldN target or most other families of orthologous proteins of actinobacteria (Fig 6). We speculate that this may imply differences in the signal responsiveness of different RsbN proteins, thereby contributing to the differences between
Al best hit to rsbN is found next to nearly all bldN orthologues in actinomycete genomes; but, strikingly, the RsbN-like proteins are much more divergent than their BldN target or most other families of orthologous proteins of actinobacteria (Fig 6). We speculate that this may imply differences in the signal responsiveness of different RsbN proteins, thereby contributing to the differences between
Itive search for orthologues of the 147 S. coelicolor TTA-containing genes (or in some cases gene clusters). We identified 19 that were widespread and frequently TTA-containing in 13 other Streptomyces genomes (Table 2). In addition, a further 10 genes or gene clusters frequently had TTA codons, even though their S. coelicolor orthologues were TTA-free (asterisks in Table 2). As 27/29 of the TTA-c
Nd their TTA codons have adaptive value to streptomycetes and not to other actinobacteria. As shown in Table 2, about half of these genes encode proteins likely to be closely implicated in gene regulation or signal transduction, although their targets are mostly unknown. They include five conserved paralogues of genes found in the whiJ cluster (see below for further discussion) and gene sets for h
Among actinobacteria) 3919* (abaB*) 3943* (rstP*) 4114 (widespread among actinobacteria) 4263 4395 5203 5460 5495 5970 6156* 6245* 6476 6681(amfC); 6685* (amfR*) 7251 7465 (cvnC13)Cellulose utilisation DNA-binding regulatory protein (WhiJ-like) Unknown Secreted AAA ATPase ADPribose pyrophosphatase Possible antisigma factor (AbaA-like) Regulatory Competence operon Major developmental regulator Unkn
Among actinobacteria) 3919* (abaB*) 3943* (rstP*) 4114 (widespread among actinobacteria) 4263 4395 5203 5460 5495 5970 6156* 6245* 6476 6681(amfC); 6685* (amfR*) 7251 7465 (cvnC13)Cellulose utilisation DNA-binding regulatory protein (WhiJ-like) Unknown Secreted AAA ATPase ADPribose pyrophosphatase Possible antisigma factor (AbaA-like) Regulatory Competence operon Major developmental regulator Unkn