Hat this (partly) reflects differences in the complement of WhiJ-like signal transduction cascades. The strikingly reduced number of paralogues in S. venezuelae (one of several streptomycetes that lack a cluster orthologous to whiJ itself) may underpin the ability of S. venezuelae to sporulate exceptionally readily and comprehensively even in submerged culture, which has led to its adoption as a m
Hat this (partly) reflects differences in the complement of WhiJ-like signal transduction cascades. The strikingly reduced number of paralogues in S. venezuelae (one of several streptomycetes that lack a cluster orthologous to whiJ itself) may underpin the ability of S. venezuelae to sporulate exceptionally readily and comprehensively even in submerged culture, which has led to its adoption as a m
T the direct or indirect targets of WhiJ regulation or about the role of the antisigma-like protein (SCO4544). The apparently repressing action of the whiJ locus raises the possibility that some or all of its paralogues may also act as developmental brakes. If so, it may be that during `normal' colony development on laboratory media, these brakes are all off ?in other words, all relevant checkpoin
Among actinobacteria) 3919* (abaB*) 3943* (rstP*) 4114 (widespread among actinobacteria) 4263 4395 5203 5460 5495 5970 6156* 6245* 6476 6681(amfC); 6685* (amfR*) 7251 7465 (cvnC13)Cellulose utilisation DNA-binding regulatory protein (WhiJ-like) Unknown Secreted AAA ATPase ADPribose pyrophosphatase Possible antisigma factor (AbaA-like) Regulatory Competence operon Major developmental regulator Unkn
Among actinobacteria) 3919* (abaB*) 3943* (rstP*) 4114 (widespread among actinobacteria) 4263 4395 5203 5460 5495 5970 6156* 6245* 6476 6681(amfC); 6685* (amfR*) 7251 7465 (cvnC13)Cellulose utilisation DNA-binding regulatory protein (WhiJ-like) Unknown Secreted AAA ATPase ADPribose pyrophosphatase Possible antisigma factor (AbaA-like) Regulatory Competence operon Major developmental regulator Unkn
Among actinobacteria) 3919* (abaB*) 3943* (rstP*) 4114 (widespread among actinobacteria) 4263 4395 5203 5460 5495 5970 6156* 6245* 6476 6681(amfC); 6685* (amfR*) 7251 7465 (cvnC13)Cellulose utilisation DNA-binding regulatory protein (WhiJ-like) Unknown Secreted AAA ATPase ADPribose pyrophosphatase Possible antisigma factor (AbaA-like) Regulatory Competence operon Major developmental regulator Unkn
Nd their TTA codons have adaptive value to streptomycetes and not to other actinobacteria. As shown in Table 2, about half of these genes encode proteins likely to be closely implicated in gene regulation or signal transduction, although their targets are mostly unknown. They include five conserved paralogues of genes found in the whiJ cluster (see below for further discussion) and gene sets for h
Tively long-established clusters. Twelve other S. coelicolor whiJ-like genes were represented in around half of streptomycetes (SCO2381*, 2865, 2869*, 3365*, 4176, 4301, 4678, 4998, 6129, 6537, 6629*, 7579) [asterisks indicate occurrence also in some other complex actinomycete(s)]; while seven others were found in four or fewer streptomycetes (SCO0704, 2246, 2253, 4543, 5125,Fig. 7. Phylogenetic a