Rioritize the fat deposits critical for reproductive success [39]. While the trade-off between growth and reproduction during the pubertal transition is readily observed and rationalized, attention is rarely directed at investment in maintenance over the same period. Our primary hypothesis here was that maintenance of the immune system might represent a substantial, flexible component of overall e
Tion (reviewed in [45]), but in human populations the relationship to immunity is often more complex. For instance, previous research in this population finds no relationship between leptin levels and acquired immune function in moderately undernourished children [46]. While the specifics of how adipose tissue influences CRP are complex, our results support a strong relationship between adiposity
Tion (reviewed in [45]), but in human populations the relationship to immunity is often more complex. For instance, previous research in this population finds no relationship between leptin levels and acquired immune function in moderately undernourished children [46]. While the specifics of how adipose tissue influences CRP are complex, our results support a strong relationship between adiposity
Urrent caloric excess, but still have very low absolute levels of adipose tissue. While organisms may use markers of energetic balance to judge whether to embark upon long term energetic projects, such as female reproduction [6], an acute immune response will demand a large amount of energy in a short period of time [3]. Given this, it may be more reliable for organisms to use signals of energetic
Urrent caloric excess, but still have very low absolute levels of adipose tissue. While organisms may use markers of energetic balance to judge whether to embark upon long term energetic projects, such as female reproduction [6], an acute immune response will demand a large amount of energy in a short period of time [3]. Given this, it may be more reliable for organisms to use signals of energetic
Ment in other energetic demands, such as reproduction or physical activity, also evidence trade-offs with nonacute immune function? Intriguingly, two recent studies support a hypothesis that there are some trade-offs between female reproductive function and higher levels of CRP. Though they do not| Shattuck-Heidorn et al.Evolution, Medicine, and Public Healthspecifically investigate non-acute CRP,
Egulates energy metabolism and storage and is also the site of immune and antibacterial responses [41, 42]. And it is well-known that a minimum level of body fat and the hormone leptin is necessary to maintain T-mediated immunity [43], and that leptin can regulate inflammatory immune processes, including stimulating Il-6 production in macrophages [44, 45]. This is congruent with our initial eviden
As an anti-inflammatory effect [51]. How other types of physical activity, such as that associated with agricultural lifestyles, relates to immune function is an important locus for future research. The dominant public health discourse concerning CRP is one of pathology and "chronic inflammation", yet for at least a decade human biologists working in non-Western populations have found lower CRP th