Nse regulator, WhiI (Fig. 3).The key developmental regulator AdpA emerged along with complex mycelial growth and is bldA-dependent only in StreptomycineaeBldD targets also include adpA, known as bldH in S. coelicolor (den Hengst et al., 2010). AdpA has been most comprehensively described in S. griseus, in which it is the agent of the effects of the hormone-like A-factor (Horinouchi, 2002). It comp
Ehalf of the Federation of European Microbiological SocietiesG. Chandra K.F. ChaterTable 2. Streptomyces genes or gene clusters that frequently contain TTA codons* SCO number of gene *asterisk means TTA codons are absent from the S. coelicolor gene 0381*;0382*;0383 0683*;0684*;0685* Fraction of TTA-containing orthologues among 14 Streptomyces genomes (see note) 6/12; 5/9; 2/10 2/12; 4/13; 2/Func
Translation (Nguyen et al., 2003; Takano et al., 2003). Translational regulation is via a very rare UUA codon in the adpA mRNA, falling between the segments encoding the two domains of AdpA. UUA is the only one of the six leucine codons to comprise only A and U residues, so the corresponding TTA codon is comparatively rare in GC-rich genomes ?it occurs in only 147 chromosomal genes in S. coelicolo
Translation (Nguyen et al., 2003; Takano et al., 2003). Translational regulation is via a very rare UUA codon in the adpA mRNA, falling between the segments encoding the two domains of AdpA. UUA is the only one of the six leucine codons to comprise only A and U residues, so the corresponding TTA codon is comparatively rare in GC-rich genomes ?it occurs in only 147 chromosomal genes in S. coelicolo
Ehalf of the Federation of European Microbiological SocietiesG. Chandra K.F. ChaterTable 2. Streptomyces genes or gene clusters that frequently contain TTA codons* SCO number of gene *asterisk means TTA codons are absent from the S. coelicolor gene 0381*;0382*;0383 0683*;0684*;0685* Fraction of TTA-containing orthologues among 14 Streptomyces genomes (see note) 6/12; 5/9; 2/10 2/12; 4/13; 2/Func
Tomyces spp: S. coelicolor (Sco), S. pristinaespiralis (Spr), S. griseus (Sgr) and S. venezuelae (Sven). High percentage identity is indicated by the intensity of red, and low identity by the intensity of green. A control table (`Concatenated') shows the comparisons for a concatenated set of seven universal proteins (AtpD, DnaA, DnaG, DnaK, GyrB, RecA, RpoB).2000). The distribution of convincing r
Tomyces spp: S. coelicolor (Sco), S. pristinaespiralis (Spr), S. griseus (Sgr) and S. venezuelae (Sven). High percentage identity is indicated by the intensity of red, and low identity by the intensity of green. A control table (`Concatenated') shows the comparisons for a concatenated set of seven universal proteins (AtpD, DnaA, DnaG, DnaK, GyrB, RecA, RpoB).2000). The distribution of convincing r
W). This emergence into the air has been suggested as a trigger for the sporulation pathway controlled by the whi genes (Claessen et al., 2006). Convincing BldN reciprocal hits (at well over 50 identity and with local synteny) were found only among morphologically complex genera of actinomycetes (Fig. 3), suggesting a close connection of bldN with the emergence of complexity (reciprocal hits with