E MRC/DFID Concordat agreement. Funding to pay the Open Access publication charge for this article was provided by Harvard University. Conflict of interest: None declared.PerspectiveFor reprint orders, please contact: reprints@futuremedicine.comMerging data from genetic and epigenetic approaches to better understand autistic spectrum disorderAutism spectrum disorder (ASD) is a complex neurod
E MRC/DFID Concordat agreement. Funding to pay the Open Access publication charge for this article was provided by Harvard University. Conflict of interest: None declared.PerspectiveFor reprint orders, please contact: reprints@futuremedicine.comMerging data from genetic and epigenetic approaches to better understand autistic spectrum disorderAutism spectrum disorder (ASD) is a complex neurod
It is difficult to parse behavioral from physiological influences without direct measurement of the growth spurt. Alternatively, changes in levels of CRP may signify broader shifts in immunocompetence, perhaps particularly in innate immunocompetence, and not be specific to the action of CRP in particular. Outside of the context of chronic disease and pathology, the functional significance of varia
Egulates energy metabolism and storage and is also the site of immune and antibacterial responses [41, 42]. And it is well-known that a minimum level of body fat and the hormone leptin is necessary to maintain T-mediated immunity [43], and that leptin can regulate inflammatory immune processes, including stimulating Il-6 production in macrophages [44, 45]. This is congruent with our initial eviden
Tion (reviewed in [45]), but in human populations the relationship to immunity is often more complex. For instance, previous research in this population finds no relationship between leptin levels and acquired immune function in moderately undernourished children [46]. While the specifics of how adipose tissue influences CRP are complex, our results support a strong relationship between adiposity
Tion (reviewed in [45]), but in human populations the relationship to immunity is often more complex. For instance, previous research in this population finds no relationship between leptin levels and acquired immune function in moderately undernourished children [46]. While the specifics of how adipose tissue influences CRP are complex, our results support a strong relationship between adiposity
Negatively predict CRP (Model 4, Table 2). These results were not affected by including individuals with CRP over 2 mg/L in the model. The association between current investment in linear growth and CRP did not extend to height. Neither height (b = ?.01, SE = 0.02, P = 0.75, R2 = 0.0001), nor a height-for-age z-score (b = ?.03 SE = 0.16, P = 0.87, R2 = 0.0003) were associated with CRP. As an alter
Ly transnational world, understanding the significance of immunological biomarkers such as CRP, in both clinical and non-clinical settings, will require integrating knowledge of how different ecological contexts influence the manifestation of non-acute immune function. While working with a subsistence agricultural population of pubertal girls has important benefits for understanding diversity in i