Y, though the correlation is relatively weak (Pearson's R = 0.22, P = 0.001). Adiposity appears to mediate the investment between immune function and growth (Fig. 5). Independent-group t-tests were conducted to compare mean log CRP levels between groups of girls based on investment in growth and adipose reserves, as defined by median splits for height velocity and global adiposity. Considering fir
Rioritize the fat deposits critical for reproductive success [39]. While the trade-off between growth and reproduction during the pubertal transition is readily observed and rationalized, attention is rarely directed at investment in maintenance over the same period. Our primary hypothesis here was that maintenance of the immune system might represent a substantial, flexible component of overall e
It is difficult to parse behavioral from physiological influences without direct measurement of the growth spurt. Alternatively, changes in levels of CRP may signify broader shifts in immunocompetence, perhaps particularly in innate immunocompetence, and not be specific to the action of CRP in particular. Outside of the context of chronic disease and pathology, the functional significance of varia
Frequent turnover, requiring some relatively constant commitment of energetic resources, though the metabolic cost of this is unknown. Our data also imply that there are meaningful differences in low levels of CRP. Interestingly, administration of human CRP to mice protects against pneumococcal infections, but not if CRP is administered after exposure to the bacteria, suggesting an early prophylac
Frequent turnover, requiring some relatively constant commitment of energetic resources, though the metabolic cost of this is unknown. Our data also imply that there are meaningful differences in low levels of CRP. Interestingly, administration of human CRP to mice protects against pneumococcal infections, but not if CRP is administered after exposure to the bacteria, suggesting an early prophylac
Y and inflammation [17]. However the inflammation induced by obesity is understood to result from-6 Lower adiposity Higher adiposity-Log CRP -Lower adiposity Higher adiposityBelow median growthAbove median growthFigure 5. Relationships between log CRP, investment in growth and adiposity. Adiposity mediates the relationship between log CRP and growth. Girls who are investing heavily in growth and h
As an anti-inflammatory effect [51]. How other types of physical activity, such as that associated with agricultural lifestyles, relates to immune function is an important locus for future research. The dominant public health discourse concerning CRP is one of pathology and "chronic inflammation", yet for at least a decade human biologists working in non-Western populations have found lower CRP th
Ly transnational world, understanding the significance of immunological biomarkers such as CRP, in both clinical and non-clinical settings, will require integrating knowledge of how different ecological contexts influence the manifestation of non-acute immune function. While working with a subsistence agricultural population of pubertal girls has important benefits for understanding diversity in i