N each cluster co-evolved (results not shown). WhiJ paralogues in S. coelicolor vary considerably in their conservation in other organisms. One (SCO3421) was present in nearly all complex actinomycetes, and the adjacent gene encoding a likely antisigma factor nearly always contained a TTA codon in Streptomycineae (but in no other groups). Another present in all Streptomycineae (SCO4441) was also w
N each cluster co-evolved (results not shown). WhiJ paralogues in S. coelicolor vary considerably in their conservation in other organisms. One (SCO3421) was present in nearly all complex actinomycetes, and the adjacent gene encoding a likely antisigma factor nearly always contained a TTA codon in Streptomycineae (but in no other groups). Another present in all Streptomycineae (SCO4441) was also w
Among actinobacteria) 3919* (abaB*) 3943* (rstP*) 4114 (widespread among actinobacteria) 4263 4395 5203 5460 5495 5970 6156* 6245* 6476 6681(amfC); 6685* (amfR*) 7251 7465 (cvnC13)Cellulose utilisation DNA-binding regulatory protein (WhiJ-like) Unknown Secreted AAA ATPase ADPribose pyrophosphatase Possible antisigma factor (AbaA-like) Regulatory Competence operon Major developmental regulator Unkn
Among actinobacteria) 3919* (abaB*) 3943* (rstP*) 4114 (widespread among actinobacteria) 4263 4395 5203 5460 5495 5970 6156* 6245* 6476 6681(amfC); 6685* (amfR*) 7251 7465 (cvnC13)Cellulose utilisation DNA-binding regulatory protein (WhiJ-like) Unknown Secreted AAA ATPase ADPribose pyrophosphatase Possible antisigma factor (AbaA-like) Regulatory Competence operon Major developmental regulator Unkn
N each cluster co-evolved (results not shown). WhiJ paralogues in S. coelicolor vary considerably in their conservation in other organisms. One (SCO3421) was present in nearly all complex actinomycetes, and the adjacent gene encoding a likely antisigma factor nearly always contained a TTA codon in Streptomycineae (but in no other groups). Another present in all Streptomycineae (SCO4441) was also w
Nd their TTA codons have adaptive value to streptomycetes and not to other actinobacteria. As shown in Table 2, about half of these genes encode proteins likely to be closely implicated in gene regulation or signal transduction, although their targets are mostly unknown. They include five conserved paralogues of genes found in the whiJ cluster (see below for further discussion) and gene sets for h
W). This emergence into the air has been suggested as a trigger for the sporulation pathway controlled by the whi genes (Claessen et al., 2006). Convincing BldN reciprocal hits (at well over 50 identity and with local synteny) were found only among morphologically complex genera of actinomycetes (Fig. 3), suggesting a close connection of bldN with the emergence of complexity (reciprocal hits with
Factor (AbaA-like) Unknown Unknown SapB biosynthetic enzyme; regulator of SapB biosynthesis Possible phosphotransferase Component of conservon6/13; 7/14 9/11 6/10 8/13 8/12 9/14 8/14 3/11; 5/13 14/14 5/14 12/14 6/14 7/13 5/14 9/14 8/11 12/14 6/14 6/14 7/14 6/13 5/14 5/13 7/14 2/12; 7/12 10/12 9/(? (?(TTA) (? (TTA) (TTA) (??40040 (? 43220 (? ??49090 50850 (TTA) 51100 (TTA) 26520 19600 (? ???16190 3