Among actinobacteria) 3919* (abaB*) 3943* (rstP*) 4114 (widespread among actinobacteria) 4263 4395 5203 5460 5495 5970 6156* 6245* 6476 6681(amfC); 6685* (amfR*) 7251 7465 (cvnC13)Cellulose utilisation DNA-binding regulatory protein (WhiJ-like) Unknown Secreted AAA ATPase ADPribose pyrophosphatase Possible antisigma factor (AbaA-like) Regulatory Competence operon Major developmental regulator Unkn
Factor (AbaA-like) Unknown Unknown SapB biosynthetic enzyme; regulator of SapB biosynthesis Possible phosphotransferase Component of conservon6/13; 7/14 9/11 6/10 8/13 8/12 9/14 8/14 3/11; 5/13 14/14 5/14 12/14 6/14 7/13 5/14 9/14 8/11 12/14 6/14 6/14 7/14 6/13 5/14 5/13 7/14 2/12; 7/12 10/12 9/(? (?(TTA) (? (TTA) (TTA) (??40040 (? 43220 (? ??49090 50850 (TTA) 51100 (TTA) 26520 19600 (? ???16190 3
Factor (AbaA-like) Unknown Unknown SapB biosynthetic enzyme; regulator of SapB biosynthesis Possible phosphotransferase Component of conservon6/13; 7/14 9/11 6/10 8/13 8/12 9/14 8/14 3/11; 5/13 14/14 5/14 12/14 6/14 7/13 5/14 9/14 8/11 12/14 6/14 6/14 7/14 6/13 5/14 5/13 7/14 2/12; 7/12 10/12 9/(? (?(TTA) (? (TTA) (TTA) (??40040 (? 43220 (? ??49090 50850 (TTA) 51100 (TTA) 26520 19600 (? ???16190 3
Factor (AbaA-like) Unknown Unknown SapB biosynthetic enzyme; regulator of SapB biosynthesis Possible phosphotransferase Component of conservon6/13; 7/14 9/11 6/10 8/13 8/12 9/14 8/14 3/11; 5/13 14/14 5/14 12/14 6/14 7/13 5/14 9/14 8/11 12/14 6/14 6/14 7/14 6/13 5/14 5/13 7/14 2/12; 7/12 10/12 9/(? (?(TTA) (? (TTA) (TTA) (??40040 (? 43220 (? ??49090 50850 (TTA) 51100 (TTA) 26520 19600 (? ???16190 3
Nd their TTA codons have adaptive value to streptomycetes and not to other actinobacteria. As shown in Table 2, about half of these genes encode proteins likely to be closely implicated in gene regulation or signal transduction, although their targets are mostly unknown. They include five conserved paralogues of genes found in the whiJ cluster (see below for further discussion) and gene sets for h
Odon in one or another gene of the cluster.towards the start of genes that is observed in streptomycetes, and sometimes occur in conserved growthassociated genes (Chater Chandra, 2008). Interestingly, there is a strong target for BldD binding within bldA (den Hengst et al., 2010).Previously unnoticed aspects of the occurrence of conserved TTA codonsEarlier analyses had indicated that most of the
There is little evidence of direct regulatory interplay between the two genes. Possibly, then, AdpA evolved to regulate aspects of developmental physiology complementary to those regulated by BldN (if so, one might anticipate that some cross-checks between the two regulons will eventually be discovered). The regulation of adpA in streptomycetes is remarkably complex (reviewed in detail in Liu et a
Translation (Nguyen et al., 2003; Takano et al., 2003). Translational regulation is via a very rare UUA codon in the adpA mRNA, falling between the segments encoding the two domains of AdpA. UUA is the only one of the six leucine codons to comprise only A and U residues, so the corresponding TTA codon is comparatively rare in GC-rich genomes ?it occurs in only 147 chromosomal genes in S. coelicolo