Ly transnational world, understanding the significance of immunological biomarkers such as CRP, in both clinical and non-clinical settings, will require integrating knowledge of how different ecological contexts influence the manifestation of non-acute immune function. While working with a subsistence agricultural population of pubertal girls has important benefits for understanding diversity in i
Tion (reviewed in [45]), but in human populations the relationship to immunity is often more complex. For instance, previous research in this population finds no relationship between leptin levels and acquired immune function in moderately undernourished children [46]. While the specifics of how adipose tissue influences CRP are complex, our results support a strong relationship between adiposity
Y, though the correlation is relatively weak (Pearson's R = 0.22, P = 0.001). Adiposity appears to mediate the investment between immune function and growth (Fig. 5). Independent-group t-tests were conducted to compare mean log CRP levels between groups of girls based on investment in growth and adipose reserves, as defined by median splits for height velocity and global adiposity. Considering fir
Y, though the correlation is relatively weak (Pearson's R = 0.22, P = 0.001). Adiposity appears to mediate the investment between immune function and growth (Fig. 5). Independent-group t-tests were conducted to compare mean log CRP levels between groups of girls based on investment in growth and adipose reserves, as defined by median splits for height velocity and global adiposity. Considering fir
Y, though the correlation is relatively weak (Pearson's R = 0.22, P = 0.001). Adiposity appears to mediate the investment between immune function and growth (Fig. 5). Independent-group t-tests were conducted to compare mean log CRP levels between groups of girls based on investment in growth and adipose reserves, as defined by median splits for height velocity and global adiposity. Considering fir
Y, though the correlation is relatively weak (Pearson's R = 0.22, P = 0.001). Adiposity appears to mediate the investment between immune function and growth (Fig. 5). Independent-group t-tests were conducted to compare mean log CRP levels between groups of girls based on investment in growth and adipose reserves, as defined by median splits for height velocity and global adiposity. Considering fir
Frequent turnover, requiring some relatively constant commitment of energetic resources, though the metabolic cost of this is unknown. Our data also imply that there are meaningful differences in low levels of CRP. Interestingly, administration of human CRP to mice protects against pneumococcal infections, but not if CRP is administered after exposure to the bacteria, suggesting an early prophylac
Frequent turnover, requiring some relatively constant commitment of energetic resources, though the metabolic cost of this is unknown. Our data also imply that there are meaningful differences in low levels of CRP. Interestingly, administration of human CRP to mice protects against pneumococcal infections, but not if CRP is administered after exposure to the bacteria, suggesting an early prophylac