The molecular goal of gemcitabine is actually ribonucleotide reductase [5]. This particular chemical catalyzes your rate-limiting step up deoxyribonucleotide development and is also the one recognized chemical in which changes ribonucleotides to deoxyribonucletides, which are required for DNA polymerization as well as restoration [6]. Your RRM1 gene encodes your regulating subunit involving ribonu