Dent power for predicting log CRP (Model 5, Table 2).Energetics and the immune systemShattuck-Heidorn et al. |pathological processes such as the increased recruitment of macrophages into adipose tissue in response to stress signals from enlarged adipocytes [40]. Here we find that CRP, in a range well below the chronic levels understood to result from obesity, is positively associated with adiposit
As an anti-inflammatory effect [51]. How other types of physical activity, such as that associated with agricultural lifestyles, relates to immune function is an important locus for future research. The dominant public health discourse concerning CRP is one of pathology and "chronic inflammation", yet for at least a decade human biologists working in non-Western populations have found lower CRP th
Y than acquired immunity [47], and may be especially sensitive to energetic indicators. The relationships between adipose tissue, leptin and immune function suggest that organisms increase innate immune vigilance when adipose tissue reserves are sufficient to fund acute immune responses. This framework, of considering the cost of an acute response as underlying the coupling of nonacute immune func
Y than acquired immunity [47], and may be especially sensitive to energetic indicators. The relationships between adipose tissue, leptin and immune function suggest that organisms increase innate immune vigilance when adipose tissue reserves are sufficient to fund acute immune responses. This framework, of considering the cost of an acute response as underlying the coupling of nonacute immune func
E both investing heavily in growth and had high adiposity, however their CRP levels (M = ?.63, SD = 0.97) did not differ significantly from girls with similar levels of adiposity who were not investing in growth (M = ?.87, SD = 1.09, t = ?.10, P = 0.28). Girls who were investing in growth and had low adiposity had the lowest CRP levels of any group (M = ?.74, SD = 1.10), significantly lower than g
Negatively predict CRP (Model 4, Table 2). These results were not affected by including individuals with CRP over 2 mg/L in the model. The association between current investment in linear growth and CRP did not extend to height. Neither height (b = ?.01, SE = 0.02, P = 0.75, R2 = 0.0001), nor a height-for-age z-score (b = ?.03 SE = 0.16, P = 0.87, R2 = 0.0003) were associated with CRP. As an alter
Ping physiological categories in ways that optimize fitness [5, 38]. The adolescent transition is a particularly useful time to consider energetic dynamics, as during puberty investment in linear growth is first increased (the adolescent growth spurt) and then terminated. Meanwhile, investment in reproduction, manifested in females as the development of primary and secondary sexual characteristics
Frequent turnover, requiring some relatively constant commitment of energetic resources, though the metabolic cost of this is unknown. Our data also imply that there are meaningful differences in low levels of CRP. Interestingly, administration of human CRP to mice protects against pneumococcal infections, but not if CRP is administered after exposure to the bacteria, suggesting an early prophylac