Licolor is the whiJ gene (SCO4543) for a deduced DNA-binding protein (Gehring et al., 2000; Ainsa et al., 2010). Most of the 24 paralogues of whiJ in the S. coelicolor chromosome are associated with one or both of two kinds of immediately neighbouring genes, one kind encoding very small DNA-binding proteins (i.e. like SCO4542) and the other encoding proteins with features like antisigma factors (e
Licolor is the whiJ gene (SCO4543) for a deduced DNA-binding protein (Gehring et al., 2000; Ainsa et al., 2010). Most of the 24 paralogues of whiJ in the S. coelicolor chromosome are associated with one or both of two kinds of immediately neighbouring genes, one kind encoding very small DNA-binding proteins (i.e. like SCO4542) and the other encoding proteins with features like antisigma factors (e
Licolor is the whiJ gene (SCO4543) for a deduced DNA-binding protein (Gehring et al., 2000; Ainsa et al., 2010). Most of the 24 paralogues of whiJ in the S. coelicolor chromosome are associated with one or both of two kinds of immediately neighbouring genes, one kind encoding very small DNA-binding proteins (i.e. like SCO4542) and the other encoding proteins with features like antisigma factors (e
There is little evidence of direct regulatory interplay between the two genes. Possibly, then, AdpA evolved to regulate aspects of developmental physiology complementary to those regulated by BldN (if so, one might anticipate that some cross-checks between the two regulons will eventually be discovered). The regulation of adpA in streptomycetes is remarkably complex (reviewed in detail in Liu et a
Licolor is the whiJ gene (SCO4543) for a deduced DNA-binding protein (Gehring et al., 2000; Ainsa et al., 2010). Most of the 24 paralogues of whiJ in the S. coelicolor chromosome are associated with one or both of two kinds of immediately neighbouring genes, one kind encoding very small DNA-binding proteins (i.e. like SCO4542) and the other encoding proteins with features like antisigma factors (e
Itive search for orthologues of the 147 S. coelicolor TTA-containing genes (or in some cases gene clusters). We identified 19 that were widespread and frequently TTA-containing in 13 other Streptomyces genomes (Table 2). In addition, a further 10 genes or gene clusters frequently had TTA codons, even though their S. coelicolor orthologues were TTA-free (asterisks in Table 2). As 27/29 of the TTA-c
Nd their TTA codons have adaptive value to streptomycetes and not to other actinobacteria. As shown in Table 2, about half of these genes encode proteins likely to be closely implicated in gene regulation or signal transduction, although their targets are mostly unknown. They include five conserved paralogues of genes found in the whiJ cluster (see below for further discussion) and gene sets for h
Licolor is the whiJ gene (SCO4543) for a deduced DNA-binding protein (Gehring et al., 2000; Ainsa et al., 2010). Most of the 24 paralogues of whiJ in the S. coelicolor chromosome are associated with one or both of two kinds of immediately neighbouring genes, one kind encoding very small DNA-binding proteins (i.e. like SCO4542) and the other encoding proteins with features like antisigma factors (e