Tively long-established clusters. Twelve other S. coelicolor whiJ-like genes were represented in around half of streptomycetes (SCO2381*, 2865, 2869*, 3365*, 4176, 4301, 4678, 4998, 6129, 6537, 6629*, 7579) [asterisks indicate occurrence also in some other complex actinomycete(s)]; while seven others were found in four or fewer streptomycetes (SCO0704, 2246, 2253, 4543, 5125,Fig. 7. Phylogenetic a
Itive search for orthologues of the 147 S. coelicolor TTA-containing genes (or in some cases gene clusters). We identified 19 that were widespread and frequently TTA-containing in 13 other Streptomyces genomes (Table 2). In addition, a further 10 genes or gene clusters frequently had TTA codons, even though their S. coelicolor orthologues were TTA-free (asterisks in Table 2). As 27/29 of the TTA-c
N each cluster co-evolved (results not shown). WhiJ paralogues in S. coelicolor vary considerably in their conservation in other organisms. One (SCO3421) was present in nearly all complex actinomycetes, and the adjacent gene encoding a likely antisigma factor nearly always contained a TTA codon in Streptomycineae (but in no other groups). Another present in all Streptomycineae (SCO4441) was also w
N each cluster co-evolved (results not shown). WhiJ paralogues in S. coelicolor vary considerably in their conservation in other organisms. One (SCO3421) was present in nearly all complex actinomycetes, and the adjacent gene encoding a likely antisigma factor nearly always contained a TTA codon in Streptomycineae (but in no other groups). Another present in all Streptomycineae (SCO4441) was also w
Among actinobacteria) 3919* (abaB*) 3943* (rstP*) 4114 (widespread among actinobacteria) 4263 4395 5203 5460 5495 5970 6156* 6245* 6476 6681(amfC); 6685* (amfR*) 7251 7465 (cvnC13)Cellulose utilisation DNA-binding regulatory protein (WhiJ-like) Unknown Secreted AAA ATPase ADPribose pyrophosphatase Possible antisigma factor (AbaA-like) Regulatory Competence operon Major developmental regulator Unkn
Among actinobacteria) 3919* (abaB*) 3943* (rstP*) 4114 (widespread among actinobacteria) 4263 4395 5203 5460 5495 5970 6156* 6245* 6476 6681(amfC); 6685* (amfR*) 7251 7465 (cvnC13)Cellulose utilisation DNA-binding regulatory protein (WhiJ-like) Unknown Secreted AAA ATPase ADPribose pyrophosphatase Possible antisigma factor (AbaA-like) Regulatory Competence operon Major developmental regulator Unkn
Itive search for orthologues of the 147 S. coelicolor TTA-containing genes (or in some cases gene clusters). We identified 19 that were widespread and frequently TTA-containing in 13 other Streptomyces genomes (Table 2). In addition, a further 10 genes or gene clusters frequently had TTA codons, even though their S. coelicolor orthologues were TTA-free (asterisks in Table 2). As 27/29 of the TTA-c
Ehalf of the Federation of European Microbiological SocietiesG. Chandra K.F. ChaterTable 2. Streptomyces genes or gene clusters that frequently contain TTA codons* SCO number of gene *asterisk means TTA codons are absent from the S. coelicolor gene 0381*;0382*;0383 0683*;0684*;0685* Fraction of TTA-containing orthologues among 14 Streptomyces genomes (see note) 6/12; 5/9; 2/10 2/12; 4/13; 2/Func