Factor (AbaA-like) Unknown Unknown SapB biosynthetic enzyme; regulator of SapB biosynthesis Possible phosphotransferase Component of conservon6/13; 7/14 9/11 6/10 8/13 8/12 9/14 8/14 3/11; 5/13 14/14 5/14 12/14 6/14 7/13 5/14 9/14 8/11 12/14 6/14 6/14 7/14 6/13 5/14 5/13 7/14 2/12; 7/12 10/12 9/(? (?(TTA) (? (TTA) (TTA) (??40040 (? 43220 (? ??49090 50850 (TTA) 51100 (TTA) 26520 19600 (? ???16190 3
Factor (AbaA-like) Unknown Unknown SapB biosynthetic enzyme; regulator of SapB biosynthesis Possible phosphotransferase Component of conservon6/13; 7/14 9/11 6/10 8/13 8/12 9/14 8/14 3/11; 5/13 14/14 5/14 12/14 6/14 7/13 5/14 9/14 8/11 12/14 6/14 6/14 7/14 6/13 5/14 5/13 7/14 2/12; 7/12 10/12 9/(? (?(TTA) (? (TTA) (TTA) (??40040 (? 43220 (? ??49090 50850 (TTA) 51100 (TTA) 26520 19600 (? ???16190 3
Nd their TTA codons have adaptive value to streptomycetes and not to other actinobacteria. As shown in Table 2, about half of these genes encode proteins likely to be closely implicated in gene regulation or signal transduction, although their targets are mostly unknown. They include five conserved paralogues of genes found in the whiJ cluster (see below for further discussion) and gene sets for h
Can hydrolase activity (Mukamolova et al., 2006; Haiser et al., 2009). Mutational analysis indicates considerable functional redundancy among RPFs in mycobacteria (reviewed by Kana Mizrahi, 2010), but phenotypic effects were observed in S. coelicolor when SCO3097 was disrupted: the mutant produced thin-walled, heat-sensitive, irregular spores in chains that tended not to separate as readily as w
Can hydrolase activity (Mukamolova et al., 2006; Haiser et al., 2009). Mutational analysis indicates considerable functional redundancy among RPFs in mycobacteria (reviewed by Kana Mizrahi, 2010), but phenotypic effects were observed in S. coelicolor when SCO3097 was disrupted: the mutant produced thin-walled, heat-sensitive, irregular spores in chains that tended not to separate as readily as w
Factor (AbaA-like) Unknown Unknown SapB biosynthetic enzyme; regulator of SapB biosynthesis Possible phosphotransferase Component of conservon6/13; 7/14 9/11 6/10 8/13 8/12 9/14 8/14 3/11; 5/13 14/14 5/14 12/14 6/14 7/13 5/14 9/14 8/11 12/14 6/14 6/14 7/14 6/13 5/14 5/13 7/14 2/12; 7/12 10/12 9/(? (?(TTA) (? (TTA) (TTA) (??40040 (? 43220 (? ??49090 50850 (TTA) 51100 (TTA) 26520 19600 (? ???16190 3
Factor (AbaA-like) Unknown Unknown SapB biosynthetic enzyme; regulator of SapB biosynthesis Possible phosphotransferase Component of conservon6/13; 7/14 9/11 6/10 8/13 8/12 9/14 8/14 3/11; 5/13 14/14 5/14 12/14 6/14 7/13 5/14 9/14 8/11 12/14 6/14 6/14 7/14 6/13 5/14 5/13 7/14 2/12; 7/12 10/12 9/(? (?(TTA) (? (TTA) (TTA) (??40040 (? 43220 (? ??49090 50850 (TTA) 51100 (TTA) 26520 19600 (? ???16190 3
N each cluster co-evolved (results not shown). WhiJ paralogues in S. coelicolor vary considerably in their conservation in other organisms. One (SCO3421) was present in nearly all complex actinomycetes, and the adjacent gene encoding a likely antisigma factor nearly always contained a TTA codon in Streptomycineae (but in no other groups). Another present in all Streptomycineae (SCO4441) was also w