Translation (Nguyen et al., 2003; Takano et al., 2003). Translational regulation is via a very rare UUA codon in the adpA mRNA, falling between the segments encoding the two domains of AdpA. UUA is the only one of the six leucine codons to comprise only A and U residues, so the corresponding TTA codon is comparatively rare in GC-rich genomes ?it occurs in only 147 chromosomal genes in S. coelicolo
W). This emergence into the air has been suggested as a trigger for the sporulation pathway controlled by the whi genes (Claessen et al., 2006). Convincing BldN reciprocal hits (at well over 50 identity and with local synteny) were found only among morphologically complex genera of actinomycetes (Fig. 3), suggesting a close connection of bldN with the emergence of complexity (reciprocal hits with
Odon in one or another gene of the cluster.towards the start of genes that is observed in streptomycetes, and sometimes occur in conserved growthassociated genes (Chater Chandra, 2008). Interestingly, there is a strong target for BldD binding within bldA (den Hengst et al., 2010).Previously unnoticed aspects of the occurrence of conserved TTA codonsEarlier analyses had indicated that most of the