Positively predicted log CRP (b = 0.16, SE = 0.04, P < 0.001, R2 = 0.17). Including individuals with CRP over 2 mg/L did not affect the model (b = 0.19, SE = 0.04, P < 0.001, R2 = 0.17). Including age and season as covariates did not influence the significance of adiposity as a predictor of CRP (Model 1, Table 2). These results suggest a relatively continuous relationship between adiposity and CRP
Frequent turnover, requiring some relatively constant commitment of energetic resources, though the metabolic cost of this is unknown. Our data also imply that there are meaningful differences in low levels of CRP. Interestingly, administration of human CRP to mice protects against pneumococcal infections, but not if CRP is administered after exposure to the bacteria, suggesting an early prophylac
Frequent turnover, requiring some relatively constant commitment of energetic resources, though the metabolic cost of this is unknown. Our data also imply that there are meaningful differences in low levels of CRP. Interestingly, administration of human CRP to mice protects against pneumococcal infections, but not if CRP is administered after exposure to the bacteria, suggesting an early prophylac
It is difficult to parse behavioral from physiological influences without direct measurement of the growth spurt. Alternatively, changes in levels of CRP may signify broader shifts in immunocompetence, perhaps particularly in innate immunocompetence, and not be specific to the action of CRP in particular. Outside of the context of chronic disease and pathology, the functional significance of varia
Iction that positive energy balance would be associated with higher investment in non-acute immune function, CRP did not differ significantly between individuals who were gaining fat within a season and those who were losing fat (b = 0.20, SE = 0.17, P = 0.24, R2 = 0.01). This finding was not affected by including individuals with CRP above 2 mg/L in the model, or by including age, season and adip
Y and inflammation [17]. However the inflammation induced by obesity is understood to result from-6 Lower adiposity Higher adiposity-Log CRP -Lower adiposity Higher adiposityBelow median growthAbove median growthFigure 5. Relationships between log CRP, investment in growth and adiposity. Adiposity mediates the relationship between log CRP and growth. Girls who are investing heavily in growth and h
Y than acquired immunity [47], and may be especially sensitive to energetic indicators. The relationships between adipose tissue, leptin and immune function suggest that organisms increase innate immune vigilance when adipose tissue reserves are sufficient to fund acute immune responses. This framework, of considering the cost of an acute response as underlying the coupling of nonacute immune func
Y than acquired immunity [47], and may be especially sensitive to energetic indicators. The relationships between adipose tissue, leptin and immune function suggest that organisms increase innate immune vigilance when adipose tissue reserves are sufficient to fund acute immune responses. This framework, of considering the cost of an acute response as underlying the coupling of nonacute immune func