Rotenone inhibits sophisticated I in the mitochondrial respiratory system archipelago and reduces oxidative phosphorylation, resulting in ATP depletion with an rise in the AMP/ATP rate, which results in excitement of AMPK phosphorylation. In the present review many of us noticed that although 2?mmol/l metformin and also 100?nmol/l rotenone experienced related results about gluconeogenesis and AMPK