This points too sufferers treated with statins have a specially high-risk of establishing DDIs, some of which can lead to drug discontinuations owing to negative activities. The best way to prevent this concern is to use any statin with a lower risk of DDIs. While lovastatin, simvastatin and atorvastatin are digested mainly by CYP3A4 and fluvastatin and also rosuvastatin are digested simply by CYP