S1 establishes picky binding; S2 is actually tiny, and usually analyzed with S4; S3, located in the side of S1, is very exposed to the particular solution surroundings; You'll find 3 ligand-binding internet domain names within S4, called ��hydrophobic cartridge (hydrophobic package)��, ��cationic gap (cationic opening)�� as well as the normal water position (normal water site). FXa inhibitor gener